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Cytochrome P450 Effect: Substrate of CYP3A4.
Increased Effect / Toxicity: CYP3A4 inhibitors: Serum level and/or toxicity of fluticasone may be increased, this effect was shown with ketoconazole, but not erythromycin. Other potential inhibitors include amiodarone, cimetidine, clarithromycin, delavirdine, diltiazem, dirithromycin, disulfiram, fluoxetine, fluvoxamine, grapefruit juice, indinavir, itraconazole, ketoconazole, nefazodone, nevirapine, propoxyphene, quinupristin-dalfopristin, ritonavir, saquinavir, verapamil, zafirlukast, zileuton.
Salmeterol: The addition of salmeterol has been demonstrated to improve response to inhaled corticosteroids (as compared to increasing steroid dosage).
Ethanol / Nutrition / Herb Interactions: Herb / Nutraceutical: In theory, St John's Wort may decrease serum levels of fluticasone by inducing CYP3A4 isoenzymes.
